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Stress-related autoimmune diseases

    The exact causes of autoimmune disorders are unclear.

However, it is known that the nervous system could have a significant contribution to the etiopathogenesis of the immune diseases, because it can modulate the physiological and immune functions.

Thus, studies on the relationship between emotions and the physiopathology of the immune system represent one of the most promising research pathways and offer hope to elucidating many enigmas posed by autoimmune diseases.
Stress and anxiety have been shown to influence a number of human inflammatory and autoimmune diseases including rheumatoid arthritis, psoriasis, fibromyalgia, inflammatory bowel disease, multiple scleroses, thyroiditis, asthma, dermatitis and many other.

Contrary to popular belief, stress and anxiety never stay in your head. Chronic stress and anxiety can result in dysfunctional patterns of secretion of the stress hormone cortisol. Deficiencies of cortisol and corticotropin-releasing hormone can compromise integrity of the gastrointestinal mucosa, leading to a pathologic intestinal permeability known as “leaky gut syndrome”, which is a prerequisite for the development of autoimmune disease. In addition, the neuropeptides, endogenous opioids, and pituitary hormones are released during exposure to stressors and affect cell-mediated and antibody-mediated immune responses.

Stress-triggered neuroendocrine hormones lead to immune deregulation, which ultimately results in autoimmune disease, by altering or amplifying cytokine production which is a cellular messenger implicated in the pathophysiology of autoimmune disease by increasing antibody cells production and tagging self-tissue for destruction. And so, since the autoimmune diseases cause significant psychological distress due to pain, fatigue, and even mobility limitations, vicious cycle ensues.

As you already know, rather than passively observing what happens to you, your subconscious mind is actually in charge of the proper functioning of your conscious mind and your body through the regulatory mechanisms of your autonomous nervous system. When you feel relaxed and safe, the sympathetic branch of the autonomous nervous system kicks in and your body is nourished, healed and the energy is restored. Whenever you are facing a threat, the parasympathetic branch of the autonomous nervous system kicks in and the stress response will mobilize all your resources for your survival inbuilt fight or flight response.

While you are in the middle of a stress response, as the stress response will mobilize all your resources for your survival, your body's nourishing, restorative. maintenance and self-repair functions come to a screeching halt. Unfortunately, when the threat is imaginary, the subconscious mind doesn't realize that there is no real threat and, over time, when this stress response is repetitively triggered by nothing but imaginary threats, nature's biological response to a threat ends up actually doing more harm than good.

Long term, if your body is not properly nourished, restored, maintained and repaired, the effects of chronic wear and tear on your body takes its toll and you will end up mentally and physically sick. Therefore, by releasing  stress and anxiety, your body creates a loop of positive feedback through the  autonomic nervous system, feedback that can rebalance your sympathetic and parasympathetic branches and lead so to significant improvement in symptoms of your stress and anxiety related autoimmun condition. The degree of improvement you can reasonably expect by relieving your persistent stress and anxiety depends on how much you feel that your emotional state affects your health issues.

When dealing with a fractured bone, the standard medical approach is to align and immobilize the bone and let it heal. Because, this ancestral approach to a broken bone works on all bones. However, when dealing with stress and anxiety, there is no such thing as a one-size-fits-all approach. Therefore the psychiatry, psychotherapy, hypnotherapy, neuro-linguistic-programming, emotional freedom tapping, pet therapy, art-therapy, mindfulness, yoga, craniosacral therapy, gravity blanket, mini-horses therapy and many other approaches based on very contradictory and yet scientific concepts, are all available to solve emotional issues.

Chronic, intense or repetitive stress and anxiety can lead to various emotional troubles and even psychiatric or physical medical conditions. However, it is good to know that stress and anxiety are not normative concepts and that they are not diseases in themselves. Although your stress and anxiety are not imaginary, there is no laboratory test available to confirm or measure them. Yet you feel them and therefore you are best positioned to assess whether or not you feel stressed or anxious.

The following autoimmune conditions may be aggravated, triggered or even caused by anxiety and stress, or may be conditions for which you may be at increased risk if you are exposed to prolonged or intense anxiety and stress.

Allergy Attacks "A new study shows that even slight stress and anxiety can substantially worsen a person’s allergic reaction to some routine allergens. Moreover, the added impact of stress and anxiety seem to linger, causing the second day of a stressed person's allergy attack to be much worse."

Arthritis "Patients often report that episodes of stress or trauma preceded the onset of their rheumatoid arthritis. While stress is nearly impossible to measure, some researchers have suggested that stressful life events, such as divorce, job loss, death of a loved one or accidents, are more common in people with rheumatoid arthritis during the six-month period before disease onset compared with the general population."

Asthma  "While feeling stressed out isn't good for your overall health, it can also trigger asthma attacks just as much as smoke, pets, polluted air, and anything else that causes your asthma to flare. The only difference — stress can be much more difficult to avoid. There's a clear connection between stress and asthma, says Jonathan Bernstein, MD, an immunologist and professor at the University of Cincinnati in Ohio, who notes that a number of published studies have shown a strong relationship, and more research is underway."

Fibromyalgia "Emotional stress appears to be a trigger for the development of fibromyalgia in a person who is already biologically at risk. In addition, many people diagnosed with fibromyalgia have psychiatric mood disorders (e.g., depression, bipolar disorder), anxiety disorders (e.g., generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, social phobia) or eating disorders (e.g. anorexia nervosa). Depression, and anxiety disorder have been linked to abnormalities in some of the same neurotransmitters that are thought to be involved in pain perception (e.g., serotonin, norepinephrine, dopamine)."

Fibromyalgia  "A number of studies have shown a link between anxiety and fibromyalgia, however, the nature of the link is not yet understood. Some experts, according to a report, "Fibromyalgia," in The New York Times, "believe that fibromyalgia is not a disease, but is rather a chronic pain condition brought on by several abnormal body responses to stress."

Immune System Deficiency "Stress wreaks havoc on the mind and body. Until now, it has not been clear exactly how stress influences disease and health. Now researchers have found that chronic psychological stress is associated with the body losing its ability to regulate the inflammatory response. The research shows for the first time that the effects of psychological stress on the body's ability to regulate inflammation can promote the development and progression of disease."

Multiple Sclerosis (MS) "The issue of MS and stress is an important one. Major life events like marriage breakdown, moving house, losing or changing jobs, losing close friends or loved ones, and so on, have a profound effect on general wellbeing. A number of published papers have looked at the subject from several angles. It appears clear that major life events, or more particularly our reaction to them, can often trigger MS attacks."

Controlling stress helps fight Lupus. “A study conducted in the Department of Medicine at the University of Granada determined that daily stress (which occurs in circumstances of little importance but of high frequency) could exacerbate the symptoms of patients suffering from lupus. In other words, controlling the stress level of those suffering from this disease allows the determination of its negative effects, such as inexplicable loss of weight, feeling of fatigue, continuous fever or pain and inflammation in joints. In other words, the treatment of daily stress, together with the usual pharmacological treatment, is a useful weapon when treating patients suffering from lupus.”

Psoriasis "Weather, stress, injury, infection, and medications, while not direct causes, are often important in triggering the disease process that initiates and worsens psoriasis. Stress and Strong Emotions. Stress, unexpressed anger, and emotional disorders, including depression and anxiety, are strongly associated with psoriasis flare-ups. Research has suggested that stress can trigger specific immune factors associated with psoriasis flares"

Rheumathoid Arthritis "Researchers have found new links between stress at work and risk of rheumatoid arthritis. Stress is now recognized as an important risk factor in the pathogenesis of rheumatoid arthritis. Long-lasting stress may lead to proinflammatory effects, because no adequate long-term anti-inflammatory responses are available, he states. In contrast to osteoarthritis, the more common form of arthritis caused by trauma or infection of a joint, rheumatoid arthritis is an autoimmune disease in which the body attacks itself."

Shingles (Herpes Zoster, Zona ) "However, emotional stress does wear away at the immune system, attacking it’s ability to defend the body against all kinds of illnesses. There are any number of types of stressful situations that can damage the immune system. For example, the death of a loved one, especially if it’s unexpected, can feel like a shock. Chronic stress at work or at home, can take their toll on health"

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Disclaimer: The above content is intended for general informational purposes and does not constitute any psychological or other medical professional advice. I don't diagnose conditions, nor do I interfere with any treatments given by your medical professional.

*The results may vary from person to person.

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